The present study aimed at the formulation of matrix tablets for colon-specific drug delivery (CSDD) system of indomethacin\n(IDM) by applying liquisolid (LS) technique. A CSDD system based on time-dependent polymethacrylates and enzyme degradable\npolysaccharides was established. Eudragit RL 100 (E-RL 100) was employed as time-dependent polymer, whereas bacterial\ndegradable polysaccharides were presented as LS systems loaded with the drug. Indomethacin-loaded LS systems were prepared\nusing different polysaccharides, namely, guar gum (GG), pectin (PEC), and chitosan (CH), as carriers separately or in mixtures of\ndifferent ratios of 1 : 3, 1 : 1, and 3 : 1. Liquisolid systems that displayed promising results concerning drug release rate in both pH 1.2\nand pH 6.8 were compressed into tablets after the addition of the calculated amount of E-RL 100 and lubrication with magnesium\nstearate and talc in the ratio of 1 : 9. It was found that E-RL 100 improved the flowability and compressibility of all LS formulations.\nThe release data revealed that all formulations succeeded to sustain drug release over a period of 24 hours. Stability study indicated\nthat PEC-based LS system as well as itsmatrix tablets was stable over the period of storage (one year) and could provide a minimum\nshelf life of two years
Loading....